| Ausztrál Victoria League - U21 | 2021/03/21 04:00 | Melbourne Knights - U21 v Hume City - U21 | D | 2-2 |
| Ausztrál Victoria League - U21 | 2021/05/21 08:15 | Oakleigh Cannons - U21 v Hume City - U21 | W | 1-2 |
| Ausztrál Victoria League - U21 | 2021/05/15 09:45 | Hume City - U21 v Heidelberg Utd - U21 | D | 0-0 |
| Ausztrál Victoria League - U21 | 2021/05/08 02:15 | Avondale - U21 v Hume City - U21 | D | 1-1 |
| Ausztrál Victoria League - U21 | 2021/05/01 07:15 | Dél Melbourne - U21 v Hume City - U21 | D | 2-2 |
| Ausztrál Victoria League - U21 | 2021/04/24 09:45 | Hume City - U21 v St Albans Saints - U21 | D | 1-1 |
| Ausztrál Victoria League - U21 | 2021/04/17 07:00 | Dandenong Thunder - U21 v Hume City - U21 | W | 1-2 |
| Ausztrál Victoria League - U21 | 2021/04/10 06:30 | Hume City - U21 v Port Melbourne - U21 | W | 3-2 |
| Ausztrál Victoria League - U21 | 2021/04/03 06:15 | Eastern Lions - U21 v Hume City - U21 | W | 3-4 |
| Ausztrál Victoria League - U21 | 2021/05/23 03:00 | Melbourne Knights - U21 v Eastern Lions - U21 | D | 1-1 |
| Ausztrál Victoria League - U21 | 2021/05/14 08:15 | Bentleigh Greens - U21 v Melbourne Knights - U21 | L | 4-1 |
| Ausztrál Victoria League - U21 | 2021/05/09 03:14 | Melbourne Knights - U21 v Dél Melbourne - U21 | D | 1-1 |
| Ausztrál Victoria League - U21 | 2021/05/02 03:00 | Melbourne Knights - U21 v Dandenong City - U21 | W | 3-2 |
| Ausztrál Victoria League - U21 | 2021/04/24 05:00 | Green Gully - U21 v Melbourne Knights - U21 | W | 1-9 |
| Ausztrál Victoria League - U21 | 2021/04/18 03:00 | Melbourne Knights - U21 v Altona Magic - U21 | D | 1-1 |
| Ausztrál Victoria League - U21 | 2021/04/09 08:15 | Oakleigh Cannons - U21 v Melbourne Knights - U21 | L | 3-1 |
| Ausztrál Victoria League - U21 | 2021/04/03 04:00 | Melbourne Knights - U21 v Heidelberg Utd - U21 | W | 1-0 |