[79] Northwestern 7-33 Michigan [7] 2021-10-23 16:00
Stadium: Michigan Stadium Round: 1
Home Manager: Jim Harbaugh Away Manager: Pat Fitzgerald
Head to Head
| NCAAF | 2018/09/29 20:30 | Michigan v Northwestern | L | 20-17 |
| NCAAF | 2015/10/10 19:30 | Michigan v Northwestern | L | 38-0 |
| NCAAF | 2014/11/08 20:30 | Northwestern v Michigan | L | 9-10 |
| NCAAF | 2012/11/10 12:00 | Michigan v Northwestern | L | 38-31 |
| NCAAF | 2011/10/08 12:00 | Northwestern v Michigan | L | 24-42 |
| NCAAF | 2008/11/15 12:00 | Michigan v Northwestern | W | 14-21 |
| NCAAF | 2007/09/29 12:00 | Northwestern v Michigan | L | 16-28 |
| NCAAF | 2006/10/28 12:00 | Michigan v Northwestern | L | 17-3 |
Home History
| NCAAF | 2021/10/16 16:00 | Rutgers v Northwestern | W | 7-21 |
| NCAAF | 2021/10/02 23:30 | Northwestern v Nebraska | L | 7-56 |
| NCAAF | 2021/09/25 16:00 | Ohio v Northwestern | W | 6-35 |
| NCAAF | 2021/09/18 20:00 | Northwestern v Duke | L | 23-30 |
| NCAAF | 2021/09/11 16:00 | Indiana State v Northwestern | W | 6-24 |
| NCAAF | 2021/09/04 01:00 | Michigan State v Northwestern | L | 38-21 |
| NCAAF | 2021/01/01 18:00 | Auburn v Northwestern | W | 19-35 |
| NCAAF | 2020/12/19 17:00 | Northwestern v Ohio State | L | 10-22 |
Away History
| NCAAF | 2021/10/09 23:30 | Michigan v Nebraska | W | 32-29 |
| NCAAF | 2021/10/02 16:00 | Michigan v Wisconsin | W | 38-17 |
| NCAAF | 2021/09/25 19:30 | Rutgers v Michigan | W | 13-20 |
| NCAAF | 2021/09/18 16:00 | Northern Illinois v Michigan | W | 10-63 |
| NCAAF | 2021/09/12 00:00 | Washington v Michigan | W | 10-31 |
| NCAAF | 2021/09/04 16:00 | Western Michigan v Michigan | W | 14-47 |
| NCAAF | 2020/11/28 17:00 | Penn State v Michigan | L | 27-17 |
| NCAAF | 2020/11/22 00:30 | Michigan v Rutgers | W | 48-42 |