| ITF W25 Loule | 10/06 11:10 | 25 | [468] Angela Fita Boluda v Despina Papamichail [210] | 6-3,6-3 | |
| ITF W80 Valencia | 09/23 10:30 | 26 | [160] Francesca Jones v Despina Papamichail [215] | 7-6,6-1 | |
| ITF W80 Valencia | 09/22 11:30 | 25 | [200] Diane Parry v Despina Papamichail [215] | 3-6,3-6 | |
| ITF W80 Valencia | 09/16 08:25 | 26 | [222] Despina Papamichail v Panna Udvardy [161] | 7-6,1-6,4-6 | |
| ITF W80 Valencia | 09/15 12:30 | 25 | [131] Ysaline Bonaventure v Despina Papamichail [222] | 4-6,2-6 | |
| ITF W25 Saint Palais Sur Mer | 09/11 12:55 | 28 | [230] Despina Papamichail v Amandine Hesse [229] | 4-6,5-7 | |
| ITF W25 Saint Palais Sur Mer | 09/10 12:30 | 27 | [397] Leolia Jeanjean v Despina Papamichail [230] | 1-6,4-6 | |
| ITF W25 Saint Palais Sur Mer | 09/09 13:25 | 26 | Laia Petretic v Despina Papamichail | 4-6,2-6 | |
| ITF W25 Saint Palais Sur Mer | 09/07 11:00 | 25 | [444] Magali Kempen v Despina Papamichail [230] | 3-6,2-6 | |
| US Open - nők | 08/26 16:35 | 15 | [229] Despina Papamichail v Dalma Galfi [152] | 6-7,1-6 | |
| US Open - nők | 08/24 22:20 | 14 | [120] Renata Zarazua v Despina Papamichail [229] | 5-7,6-7 | |
| ITF W60 San Bartolome De Tirajana | 08/11 08:30 | 25 | [226] Despina Papamichail v Barbara Gatica [349] | 3-6,6-7 | |
| ITF W60 Grodzisk Mazowiecki | 07/30 09:00 | 27 | [185] Ekaterine Gorgodze v Despina Papamichail [227] | 6-3,6-0 | |
| ITF W60 Grodzisk Mazowiecki | 07/29 10:05 | 26 | [371] Martyna Kubka v Despina Papamichail [227] | 3-6,4-6 | |
| ITF W60 Grodzisk Mazowiecki | 07/28 10:00 | 25 | Andrea Gamiz v Despina Papamichail | 6-3,3-6,6-7 | |
| WTA Palermo | 07/18 17:45 | 19 | [199] Despina Papamichail v Katharina Gerlach [225] | 4-6,6-2,5-7 | |
| WTA Palermo | 07/17 19:25 | 14 | [199] Despina Papamichail v Dalila Spiteri [499] | 3-6,7-5,6-2 | |
| ITF W60 Amstelveen | 07/09 10:00 | 27 | [282] Alexandra Cadantu v Despina Papamichail [227] | 3-6,6-3,6-4 | |
| ITF W60 Amstelveen | 07/08 12:10 | 26 | [478] Andreea Prisacariu v Despina Papamichail [227] | 4-6,4-6 | |
| ITF W60 Amstelveen | 07/07 09:55 | 25 | [255] Chloe Paquet v Despina Papamichail [227] | 6-2,4-6,3-6 | |
| ITF W25 Wroclaw | 07/01 13:10 | 26 | [437] Weronika Falkowska v Despina Papamichail [227] | 4-6,6-3,6-4 | |
| ITF W25 Wroclaw | 06/30 09:30 | 25 | Nikola Tomanova v Despina Papamichail | 3-6,3-6 | |
| ITF W60 Charleston | 06/27 14:55 | 29 | [240] Gabriela Ce v Despina Papamichail [227] | 6-1,3-6,3-6 | |
| ITF W60 Charleston | 06/26 13:55 | 28 | [372] Fernanda Contreras Gomez v Despina Papamichail [261] | 2-6,2-6 | |
| ITF W60 Charleston | 06/25 13:55 | 27 | [300] Alexa Glatch v Despina Papamichail [261] | 6-4,0-6,4-6 | |
| ITF W60 Charleston | 06/24 16:40 | 26 | Charlotte Chavatipon v Despina Papamichail | 3-6,3-6 | |
| ITF W60 Charleston | 06/23 13:30 | 25 | [368] Aldila Sutjiadi v Despina Papamichail [261] | 6-2,3-6,1-6 | |
| ITF W25 Jonkoping - nők | 06/14 12:25 | 25 | [395] Camilla Rosatello v Despina Papamichail [258] | 7-5,6-3 | |
| ITF W25 Grado | 06/02 17:45 | 26 | [106] Liudmila Samsonova v Despina Papamichail [269] | 6-0,6-4 | |
| ITF W25 Grado | 06/01 10:25 | 25 | Melania Delai v Despina Papamichail | 6-7,5-7 |
Despina Papamichail (Greek: Δέσποινα Παπαμιχαήλ; born 9 February 1993) is a Greek professional tennis player. She has a career-high singles ranking of world No. 147, reached on 20 June 2022. Her highest doubles ranking is No. 93, achieved on 4 December 2023. Papamichail has won two doubles titles on the WTA Challenger Tour as well as 15 singles and 37 doubles titles on the ITF Women's Circuit.
Playing for the Greece Fed Cup team, Papamichail has a win–loss record of 31–29 (as of May 2024).
In June 2021, Papamichail won the inaugural $60k Charleston Pro event by defeating Gabriela Cé, her first title above $25k level.
She made her WTA Tour main-draw debut 2021 at the WTA 500 event in Abu Dhabi.
At the 2023 United Cup, she started the season with a win over Isabella Shinikova.
Later, she qualified for the Pan Pacific Open and defeated lucky loser Sakura Hosogi.